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Article

Smads are the central component in transforming growth factor-beta signaling.

Pharmacology & therapeutics - 1 Apr 1998

Padgett R W, Cho S H, Evangelista C

Abstract excerpt

Until recently, little was known about how transforming growth factor (TGF)-beta signals are transduced to the nucleus. With the discovery of the Smad proteins initially in Drosophila and C. elegans, the unraveling of the pathway has begun. Nine different vertebrate members also have been reported, indicating that Smads are a conserved component of the TGF-beta pathway. Currently, there are three functional...

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PMID: 9593329
DOI: 10.1016/s0163-7258(97)00166-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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