Article
A rare transporter associated with antigen processing polymorphism overpresented in HLAlow colon cancer reveals the functional significance of the signature domain in antigen processing.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2005
Yang Tianyu, Lapinski Philip E, Zhao Haotian, Zhou Qunmin, Zhang Huiming, Raghavan Malini, Liu Yang, Zheng Pan
Abstract excerpt
Transporter associated with antigen processing (TAP), a member of the ATP-binding cassette transporter superfamily, is composed of two integral membrane proteins, TAP-1 and TAP-2. Each subunit has a C-terminal nucleotide-binding domain that binds and hydrolyzes ATP to energize peptide translocation across the endoplasmic reticulum membrane. A motif comprising the sequence LSGGQ (called the signature motif) and...
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