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Article

The LMP7-K allele of the immunoproteasome exhibits reduced transcript stability and predicts high risk of colon cancer.

Cancer research - 1 Dec 2011

Fellerhoff Barbara, Gu Songhai, Laumbacher Barbara, Nerlich Andreas G, Weiss Elisabeth H, Glas Jürgen, Kopp Reinhard, Johnson Judith P, Wank Rudolf

Abstract excerpt

Destruction of cancer cells by cytotoxic T lymphocytes depends on immunogenic tumor peptides generated by proteasomes and presented by human leukocyte antigen (HLA) molecules. Functional differences arising from alleles of immunoproteasome subunits have not been recognized so far. We analyzed the genetic polymorphism of the immunoproteasome subunits LMP2 and LMP7 and of the transporters associated with antigen...

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Source

Identifiers

PMID: 22037870
DOI: 10.1158/0008-5472.CAN-10-1883

Genes

TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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