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Article

MUTYH-associated polyposis carcinomas frequently lose HLA class I expression - a common event amongst DNA-repair-deficient colorectal cancers.

The Journal of pathology - 1 Sept 2009

de Miranda Noel F C C, Nielsen Maartje, Pereira Dina, van Puijenbroek Marjo, Vasen Hans F, Hes Frederik J, van Wezel Tom, Morreau Hans

Abstract excerpt

Human leukocyte antigen (HLA) class I expression defects frequently occur in colorectal cancers bearing mismatch repair (MMR) deficiencies and are interpreted as immune evasion mechanisms to avoid cancer cell recognition and elimination by the immune system. MMR-deficient tumours are thought to be more prone to lose HLA class I expression, due to their frequent generation of aberrant peptides which can stimulate...

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Source

Identifiers

PMID: 19462419
DOI: 10.1002/path.2569

Genes

MUTYH
TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MUTYH-associated polyposis carcinomas frequently lose HLA class I expression - a common event amongst DNA-repair-deficient colorectal cancers.PMID 19462419Read ↗

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