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Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentation

2024-10-02

Abstract excerpt

<h4>ABSTRACT</h4> The abundance of MHC-I on the cell surface depends on its association with antigenic peptides transported to the endoplasmic reticulum by the Transporter Associated with Antigen Processing (TAP), a peptide channel composed of TAP1 and TAP2. We functionally screened over 1400 TAP2 variants for effects on MHC-I cell surface abundance. Amino-acid substitutions of loss of function (LOF) variants clu...

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Literature Corpus work
a0643227-7af2-501b-a992-473abda6e686
DOI
10.1101/2024.09.30.615919
Open publication

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Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentationDOI 10.1101/2024.09.30.615919
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