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Article

A single polymorphic residue within the peptide-binding cleft of MHC class I molecules determines spectrum of tapasin dependence.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2003

Park Boyoun, Lee Sungwook, Kim Euijae, Ahn Kwangseog

Abstract excerpt

Different HLA class I alleles display a distinctive dependence on tapasin for surface expression and Ag presentation. In this study, we show that the tapasin dependence of HLA class I alleles correlates to the nature of the amino acid residues present at the naturally polymorphic position 114. The tapasin dependence of HLA class I alleles bearing different residues at position 114 decreases in the order of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12517962
DOI: 10.4049/jimmunol.170.2.961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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