Allelic variants of the human putative peptide transporter involved in antigen processing.

doi:10.1073/pnas.89.9.3932

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Article

Allelic variants of the human putative peptide transporter involved in antigen processing.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1992

Colonna M, Bresnahan M, Bahram S, Strominger J L, Spies T

Abstract excerpt

Antigen processing for presentation of peptide epitopes by major histocompatibility complex (MHC) class I molecules involves genes in the MHC class II region. Among these, PSF1 and PSF2 encode subunits of a transporter, which presumably delivers cytosolic peptides across the endoplasmic reticulum membrane to class I molecules. This close functional relationship of the transporter and class I heavy chain genes and...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP-Binding Cassette Transporters
Alleles
Antigens
Base Sequence
Carrier Proteins
Celiac Disease
Diabetes Mellitus, Type 1
Haplotypes
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Major Histocompatibility Complex

Membrane Proteins

Molecular Sequence Data

Oligonucleotide Probes

Polymerase Chain Reaction

Spondylitis, Ankylosing

Source

Open in PubMed Open full text

Identifiers

PMID: 1570316
DOI: 10.1073/pnas.89.9.3932
PMCID: PMC525605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1570316-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Allelic variants of the human putative peptide transporter involved in antigen processing.PMID 1570316Read ↗

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