Article
DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells.
Journal of dermatological science - 1 Aug 2005
Matos Teresa J, Duarte Carlos B, Gonçalo Margarida, Lopes M Celeste
Abstract excerpt
BACKGROUND: The intracellular mechanisms involved in the activation of DCs during sensitization in allergic contact dermatitis (ACD) are not known. OBJECTIVE: Here, we investigated the effect of a strong sensitizer, 2,4-dinitrofluorobenzene (DNFB) on the activity of MAPKs in a dendritic cell (DC) line generated from fetal mouse skin (FSDC), and the results were correlated with the expression of a costimulatory...
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