Major histocompatibility complex class I‐restricted CD8⁺ T cells and class II‐restricted CD4⁺ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene

Abstract excerpt

Contact sensitivity (CS) is a form of delayed-type hypersensitivity to haptens applied epicutaneously and is thought to be mediated, like classical delayed-type hypersensitivity responses, by CD4+ T helper-1 cells. The aim of this study was to identify the effector T cells involved in CS. We studied CS to the strongly sensitizing hapten dinitrofluorobenzene (DNFB) in mice rendered deficient by homologous...

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