Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.

The Journal of biological chemistry - 10 May 2002

Mann Jelena, Oakley Fiona, Johnson Peter W M, Mann Derek A

Abstract excerpt

CD40-induced activation of cytokine gene expression in dendritic cells (DC) is an important process in the initiation of primary immune responses. We have determined the intracellular signaling events that lead to CD40 ligation-induced activation of interleukin-6 (IL-6) gene transcription in a murine DC line, FSDC, that is phenotypically representative of bone marrow-derived DC. IL-6 reverse transcriptase-PCR and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to CD40 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Cells

Share to Luciferases

Share to NF-kappa B

Share to Proto-Oncogene Proteins c-jun

Share to TNF Receptor-Associated Factor 2

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 11886848
DOI: 10.1074/jbc.M109250200

Genes

TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.PMID 11886848Read ↗

Differential activation profiles of multiple transcription factors during dendritic cell maturation.Semantic proximity Read ↗

TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation.Semantic proximity Read ↗

Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 DifferentiationSemantic proximity Read ↗

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development.Semantic proximity Read ↗

HIF-1beta Positively Regulates NF-kappaB Activity via Direct Control of TRAF6Semantic proximity Read ↗

Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBPSemantic proximity Read ↗

JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells.Semantic proximity Read ↗

Selective blockade of NF-kappaB by novel mutated IkappaBalpha suppresses CD3/CD28-induced activation of memory CD4+ T cells in asthma.Semantic proximity Read ↗

Varicella-Zoster Virus Inhibition of the NF-κB Pathway during Infection of Human Dendritic Cells: Role for Open Reading Frame 61 as a Modulator of NF-κB ActivitySemantic proximity Read ↗

Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor α.Semantic proximity Read ↗

Effects of adenoviral gene transfer of mutated IkappaBalpha, a novel inhibitor of NF-kappaB, on human monocyte-derived dendritic cells.Semantic proximity Read ↗

Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.