Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3.

Cellular signalling - 1 Aug 2005

Rutherford Claire, Ord-Shrimpton Fiona U, Sands William A, Pediani John D, Benovic Jeffrey L, McGrath John C, Palmer Timothy M

Abstract excerpt

Here we demonstrate that phosphorylation of the sphingosine-1-phosphate (S1P) receptor S1P(3) is increased specifically in response to S1P. Truncation of the receptor's carboxyl-terminal domain revealed that the presence of a serine-rich stretch of residues between Leu332 and Val352 was essential to observe this effect. Although agonist-occupied wild-type (WT) S1P(3) could be phosphorylated in vitro by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotinylation
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetinae

Share to Epitopes

Share to Immunoblotting

Share to In Vitro Techniques

Share to NF-kappa B

Share to Serine

Source

Identifiers

PMID: 15894172
DOI: 10.1016/j.cellsig.2004.11.018

Genes

GRK2
GRK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3.PMID 15894172Read ↗

Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain.Semantic proximity Read ↗

S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.Semantic proximity Read ↗

Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor.Semantic proximity Read ↗

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha.Semantic proximity Read ↗

Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacologySemantic proximity Read ↗

Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.Semantic proximity Read ↗

CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4.Semantic proximity Read ↗

Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.Semantic proximity Read ↗

GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.Semantic proximity Read ↗

Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.Semantic proximity Read ↗

LPA3 Receptor Phosphorylation Sites: Roles in Signaling and Internalization.Semantic proximity Read ↗

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.