Declining Efficacy of Artemisinin Combination Therapy Against <i>P. Falciparum</i> Malaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors

Abstract excerpt

BACKGROUND: Deployment of mefloquine-artesunate (MAS3) on the Thailand-Myanmar border has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has declined substantially in recent years. The role of Plasmodium falciparum K13 mutations (a marker of artemisinin resistance) in reducing treatment efficacy remains controversial. METHODS: Between 2003 and 2013, we studied the efficacy of...

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