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Article

Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border.

The American journal of tropical medicine and hygiene - 1 Apr 2007

Alker Alisa P, Lim Pharath, Sem Rithy, Shah Naman K, Yi Poravuth, Bouth Denis Mey, Tsuyuoka Reiko, Maguire Jason D, Fandeur Thierry, Ariey Frederic, Wongsrichanalai Chansuda, Meshnick Steven R

Abstract excerpt

Artemisinin combination therapies (ACTs) have recently been adopted as first-line therapy for Plasmodium falciparum infections in most malaria-endemic countries. In this study, we estimated the association between artesunate-mefloquine therapy failure and genetic changes in the putative transporter, pfmdr1. Blood samples were acquired from 80 patients enrolled in an 2004 in vivo efficacy study in Pailin,...

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PMID: 17426163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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