Article
In vitro susceptibility and genetic variations for chloroquine and mefloquine in Plasmodium falciparum isolates from Thai-Myanmar border.
The Southeast Asian journal of tropical medicine and public health - 1 Jan 2005
Hatabu Toshimitsu, Kawazu Shin-ichiro, Kojima Somei, Sato Kumiko, Singhasivanon Pratap, Looareesuwan Sornchai, Kano Shigeyuki
Abstract excerpt
In vitro drug susceptibility to chloroquine (CQ) and mefloquine (MF) were assessed in 39 P. falciparum isolates from the Thai-Myanmar border area. To further characterize CQ- and MF-resistance profiles in this area, we also analyzed pfcrt K76T mutation that is critical for CQ resistance, and pfmdr1 polymorphism that has an association with MF resistance. Eighteen isolates were successfully examined by in vitro...
Topics
- Animals
- Chloroquine
- Disease Susceptibility
- Drug Resistance, Microbial
- Genetic Variation
- Humans
- In Vitro Techniques
- Malaria
- Mefloquine
- Mutation