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Article

Differentiation of C2C12 myoblasts is critically regulated by FAK signaling.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2005

Clemente Carolina F M Z, Corat Marcus A F, Saad Sara T O, Franchini Kleber G

Abstract excerpt

This study examined whether focal adhesion kinase (FAK) plays a role in the differentiation of C(2)C(12) myoblasts into myotubes. Differentiation of C(2)C(12) myoblasts induced by switch to differentiation culture medium was accompanied by a transient reduction of FAK phosphorylation at Tyr-397 (to approximately 50%, at 1 and 2 h), followed by an increase thereafter (to 240% up to 5 days), although FAK protein...

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Identifiers

PMID: 15890789
DOI: 10.1152/ajpregu.00348.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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