Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion.

doi:10.1074/jbc.M403546200

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Article

Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion.

The Journal of biological chemistry - 5 Nov 2004

Nishiyama Tomoko, Kii Isao, Kudo Akira

Abstract excerpt

Myoblast fusion is a critical process for the terminal differentiation of skeletal muscle. To elucidate the intracellular mechanisms regulating myoblast fusion, we studied the roles of signaling through the small GTPase Rho and its effector, the Rho-associated kinase ROCK, in myoblast fusion of mouse C2C12 cells. We found that Rho activity, which was high in proliferating myoblasts, decreased during myogenesis....

Topics

Active Transport, Cell Nucleus
Amides
Animals
Cell Line
Cell Nucleus
Cell Proliferation
Culture Media
Cytoplasm
Dose-Response Relationship, Drug
Down-Regulation
Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Forkhead Box Protein O1

Forkhead Transcription Factors

GTP Phosphohydrolases

Guanosine Triphosphate

Histones

Intracellular Signaling Peptides and Proteins

Mice

Source

Open in PubMed

Identifiers

PMID: 15322110
DOI: 10.1074/jbc.M403546200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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