Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion.

The Journal of biological chemistry - 5 Nov 2004

Nishiyama Tomoko, Kii Isao, Kudo Akira

Abstract excerpt

Myoblast fusion is a critical process for the terminal differentiation of skeletal muscle. To elucidate the intracellular mechanisms regulating myoblast fusion, we studied the roles of signaling through the small GTPase Rho and its effector, the Rho-associated kinase ROCK, in myoblast fusion of mouse C2C12 cells. We found that Rho activity, which was high in proliferating myoblasts, decreased during myogenesis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Amides
Share to Forkhead Box Protein O1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Guanosine Triphosphate

Share to Myoblasts

Share to Pyridines

Share to rho-Associated Kinases

Source

Identifiers

PMID: 15322110
DOI: 10.1074/jbc.M403546200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion.PMID 15322110Read ↗

Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6.Semantic proximity Read ↗

Myogenic differentiation depends on the interplay of Grb2 and N-WASP.Semantic proximity Read ↗

Myomaker is required for the fusion of fast-twitch myocytes in the zebrafish embryo.Semantic proximity Read ↗

Myocyte-derived Myomaker expression is required for regenerative fusion but exacerbates membrane instability in dystrophic myofibersSemantic proximity Read ↗

Transient cardiomyocyte fusion regulates cardiac development in zebrafishSemantic proximity Read ↗

PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site.Semantic proximity Read ↗

Positive regulation of skeletal myogenesis by R-Ras.Semantic proximity Read ↗

The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts.Semantic proximity Read ↗

Pax7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD.Semantic proximity Read ↗

SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion.Semantic proximity Read ↗

Involvement of protein phosphatase-1-mediated MARCKS translocation in myogenic differentiation of embryonic muscle cells.Semantic proximity Read ↗

Rap1A protein interferes with various MAP kinase activating pathways in skeletal myogenic cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.