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Article

Myogenic differentiation depends on the interplay of Grb2 and N-WASP.

Biochimica et biophysica acta. Molecular cell research - 1 Mar 2017

Mitra Payal, Thanabalu Thirumaran

Abstract excerpt

Myogenesis requires a well-coordinated withdrawal from cell cycle, morphological changes and cell fusion mediated by actin cytoskeleton. Grb2 is an adaptor protein whose central SH2 domain binds to phosphorylated tyrosine residues of activated receptors and activates intracellular signaling pathway, while its N-terminal and C-terminal SH3 domains bind to proline rich proteins such as N-WASP (Neural-Wiskott...

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Identifiers

PMID: 27965114
DOI: 10.1016/j.bbamcr.2016.12.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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