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Article

FAK regulates Cdk2 in EGF-stimulated primary cultures of hepatocytes.

Journal of cellular physiology - 1 Jun 2013

Flinder Liv Ingrid, Wierød Lene, Rosseland Carola M, Huitfeldt Henrik S, Skarpen Ellen

Abstract excerpt

In this study, we report a novel role of FAK as a regulator of Cdk2 in anchorage-dependent primary cultured hepatocytes. In response to EGF, we found that S-phase entry was reduced upon FAK inhibition. This correlated with decreased protein expression and nuclear accumulation of the G1/S-phase regulator Cdk2. Further, nuclear accumulation of the Cdk2 partner cyclinE, was reduced, but not its protein level. Also,...

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Source

Identifiers

PMID: 23168795
DOI: 10.1002/jcp.24287

Genes

EGF
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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