Article
Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia.
American journal of hematology - 1 Aug 1992
Yamamoto K, Hirosawa S, Sakamaki H, Aoki N
Abstract excerpt
To investigate leukemogenesis of acute promyelocytic leukemia (APL), we studied the involvements of retinoic acid receptor alpha (RAR alpha) and myl genes, and also the frequency of N-RAS, K-RAS, H-RAS, and FMS point mutations in sixteen patients with APL. By Southern blot analysis, the rearrangements of RAR alpha gene were detected in 13 patients (81.2%), and myl gene in 14 (87.5%). Either RAR alpha or myl gene...
Topics
- Adolescent
- Adult
- Base Sequence
- Blotting, Southern
- Carrier Proteins
- Child
- Child, Preschool
- Chromosomes
- Female
- Gene Rearrangement
- Genes, fms