Article
Frequency of RAS and p53 mutations in acute promyelocytic leukemias.
Leukemia & lymphoma - 1 Nov 1993
Longo L, Trecca D, Biondi A, Lo Coco F, Grignani F, Maiolo A T, Pelicci P G, Neri A
Abstract excerpt
The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It...
Topics
- Base Sequence
- Genes, p53
- Genes, ras
- Humans
- Leukemia, Promyelocytic, Acute
- Molecular Sequence Data
- Mutation