High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis.

doi:10.1002/path.1783

Article

High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis.

The Journal of pathology - 1 Jul 2005

Riemersma Sietske A, Oudejans Joost J, Vonk Marcel J, Dreef Enno J, Prins Frans A, Jansen Patty M, Vermeer Maarten H, Blok Paul, Kibbelaar Robbie E, Muris Jettie J F, Schuuring Ed M D, Kluin Philip M

Abstract excerpt

Loss of both HLA class I and class II expression in B cell lymphomas is a mechanism of escape from a cytotoxic T lymphocyte (CTL) immune response and will therefore give a strong selective survival advantage in tumours expressing strong immunogenic antigens. We investigated loss of HLA expression using specific antibodies on tissue sections from 254 B cell lymphomas originating from nodal and different extranodal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis.

Abstract excerpt

Topics

High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis.

Abstract excerpt

Topics

Related research