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Article

The transition from HLA-I positive to HLA-I negative primary tumors: the road to escape from T-cell responses.

Current opinion in immunology - 1 Apr 2018

Aptsiauri Natalia, Ruiz-Cabello Francisco, Garrido Federico

Abstract excerpt

MHC/HLA class I loss in cancer is one of the main mechanisms of tumor immune escape from T-cell recognition and destruction. Tumor infiltration by T lymphocytes (TILs) and by other immune cells was first described many years ago, but has never been directly and clearly linked to the destruction of HLA-I positive and selection of HLA-I negative tumor cells. The degree and the pattern of lymphocyte infiltration in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29567511
DOI: 10.1016/j.coi.2018.03.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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