Article
Loss of heterozygosity, a frequent but a non-exclusive mechanism responsible for HLA dysregulation in non-Hodgkin's lymphomas.
British journal of haematology - 1 Oct 2004
Drénou Bernard, Tilanus Marcel, Semana Gilbert, Alizadeh Mehdi, Birebent Brigitte, Grosset Jean-Marc, Dias Patricia, van Wichen Dick, Arts Yvonne, De Santis Dianne, Fauchet Renée, Amiot Laurence
Abstract excerpt
The frequent alteration of human leucocyte antigen (HLA) class I molecule expression observed in non-Hodgkin's lymphomas (NHL), similarly to solid tumours, has been reported to favour tumoral escape from the immune system. In order to identify the underlying mechanisms, we analysed 15 HLA defective NHL including partial (n = 10) and total class I (n = 5) loss, as well as HLA class II defects (n = 5). The HLA...
Topics
- Flow Cytometry
- Gene Expression
- Genotype
- HLA Antigens
- HLA-DR Antigens
- Histocompatibility Antigens Class I
- Humans
- Loss of Heterozygosity
- Lymphoma, Non-Hodgkin
- Microsatellite Repeats
- RNA, Messenger
- RNA, Neoplasm