Article
Human monoclonal antibodies as a tool for the detection of HLA class I allele-specific expression loss in head-and-neck squamous cell carcinoma and corresponding lymph node metastases.
Human immunology - 1 Sept 2006
Koene Geert, Mulder Arend, van der Ven Kevin, Eijsink Chantal, Franke Marry, Slootweg Piet, Claas Frans, Tilanus Marcel
Abstract excerpt
Human leukocyte antigen (HLA) expression is important for the elimination of tumor cells by the immune system and immunotherapy. Activated T cells directed against tumor-associated antigens are fully capable of recognizing and eradicating neoplastic cells. Therefore, HLA expression loss is considered to be a main factor in tumor development. We report for the first time HLA-A and HLA-B allele-specific expression...
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