Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the HLA class II genes leading to loss of expression of HLA-DR and HLA-DQ in diffuse large B-cell lymphoma.

Immunogenetics - 1 Jul 2003

Jordanova Ekaterina S, Philippo Katja, Giphart Marius J, Schuuring Ed, Kluin Philip M

Abstract excerpt

Loss of expression of human leukocyte antigen (HLA) class II molecules on tumor cells affects the onset and modulation of the immune response through lack of activation of CD4+ T lymphocytes. Previously, we showed that the frequent loss of expression of HLA class II in diffuse large B-cell lymphoma (DLBCL) of the testis and the central nervous system (CNS) is mainly due to homozygous deletions in the HLA region...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Terminator
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-DQ alpha-Chains

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

Share to HLA-DRB1 Chains

Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Source

Identifiers

PMID: 12756506
DOI: 10.1007/s00251-003-0563-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the HLA class II genes leading to loss of expression of HLA-DR and HLA-DQ in diffuse large B-cell lymphoma.PMID 12756506Read ↗

Hemizygous deletions in the HLA region account for loss of heterozygosity in the majority of diffuse large B-cell lymphomas of the testis and the central nervous system.Semantic proximity Read ↗

Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sitesSemantic proximity Read ↗

Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Beta2-microglobulin aberrations in diffuse large B-cell lymphoma of the testis and the central nervous system.Semantic proximity Read ↗

Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphomaSemantic proximity Read ↗

Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Molecular Profiling ProjectSemantic proximity Read ↗

Loss of heterozygosity, a frequent but a non-exclusive mechanism responsible for HLA dysregulation in non-Hodgkin's lymphomas.Semantic proximity Read ↗

Human leukocyte antigen-G polymorphisms influence the clinical outcome in diffuse large B-cell lymphoma.Semantic proximity Read ↗

LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult GlioblastomaSemantic proximity Read ↗

Genetic alterations of HLA-class II in ovarian cancer.Semantic proximity Read ↗

Loss of an HLA haplotype in pancreas cancer tissue and its corresponding tumor derived cell line.Semantic proximity Read ↗

Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.