Article
Tumour MHC class I downregulation and immunotherapy (Review).
Oncology reports - 1 Jan 2000
Bubeník Jan
Abstract excerpt
MHC class I downregulation is an important mechanism of tumour escape from T cell-mediated immune responses. Approximately 40-90% of human tumours derived from various MHC class I+ tissues were reported to be MHC class I deficient. Decreased or absent MHC class I expression is frequently associated with the invasive and metastatic tumour phenotype. Altered MHC class I antigen expression involves total loss, loss...
Topics
Join the communities discussing this publication.