Article
Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2005
Delorme Richard, Betancur Catalina, Callebert Jacques, Chabane Nadia, Laplanche Jean-Louis, Mouren-Simeoni Marie-Christine, Launay Jean-Marie, Leboyer Marion
Abstract excerpt
Although compelling evidence has shown that obsessive-compulsive disorder (OCD) has a strong genetic component, its genetic basis remains to be elucidated. Identifying biological abnormalities in nonaffected relatives is one of the strategies advocated to isolate genetic vulnerability factors in complex disorders. Since peripheral serotonergic disturbances are frequently observed in OCD patients, the aim of this...
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