Article
Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder.
Molecular psychiatry - 1 Sept 1999
Bengel D, Greenberg B D, Corá-Locatelli G, Altemus M, Heils A, Li Q, Murphy D L
Abstract excerpt
Although modulation of symptoms of obsessive-compulsive disorder (OCD) by serotonergic agents is well established, it is unclear whether an abnormality in the central serotonergic system is involved in its etiology. The serotonin (5-HT) transporter (5-HTT), which is the key modulator of serotonergic neurotransmission, is the target for serotonin reuptake inhibiting drugs (SRIs) that are uniquely effective in the...
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