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Article

Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p.

Molecular genetics and genomics : MGG - 1 Jun 2005

Brunson Lee Ellen, Dixon Cheryl, LeFebvre Aaron, Sun Lisa, Mathias Neal

Abstract excerpt

The SCF family of ubiquitin-ligases consists of a common core machinery, namelySkp1p, Cdc53p, Hrt1p, and a variable component, the F-box protein that is responsible for substrate recognition. The F-box motif, which consists of approximately 40 amino acids, connects the F-box protein to the core ubiquitin-ligase machinery. Distinct SCF complexes, defined by distinct F-box proteins, target different substrate...

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Share to Basic-Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione Transferase

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Source

Identifiers

PMID: 15883825
DOI: 10.1007/s00438-005-1137-6

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p.PMID 15883825Read ↗

The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability.Semantic proximity Read ↗

Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.Semantic proximity Read ↗

The amino-terminal portion of the F-box protein Met30p mediates its nuclear import and assimilation into an SCF complex.Semantic proximity Read ↗

Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats.Semantic proximity Read ↗

A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32.Semantic proximity Read ↗

Overproduction of polypeptides corresponding to the amino terminus of the F-box proteins Cdc4p and Met30p inhibits ubiquitin ligase activities of their SCF complexes.Semantic proximity Read ↗

Cdc48 cofactor Shp1 regulates signal-induced SCFMet30 disassembly.Semantic proximity Read ↗

Characterizing the roles of Met31 and Met32 in coordinating Met4-activated transcription in the absence of Met30.Semantic proximity Read ↗

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition.Semantic proximity Read ↗

The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle.Semantic proximity Read ↗

The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer.Semantic proximity Read ↗

Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37.Semantic proximity Read ↗

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