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Article

The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability.

Molecular and cellular biology - 1 Nov 2000

Smothers D B, Kozubowski L, Dixon C, Goebl M G, Mathias N

Abstract excerpt

Ubiquitin-mediated degradation plays a crucial role in many fundamental biological pathways, including the mediation of cellular responses to changes in environmental conditions. A family of ubiquitin ligase complexes, called SCF complexes, found throughout eukaryotes, is involved in a variety of...

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Identifiers

PMID: 11027256
DOI: 10.1128/MCB.20.21.7845-7852.2000
PMCID: PMC86396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-11027256-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability.PMID 11027256Read ↗

Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p.Semantic proximity Read ↗

Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.Semantic proximity Read ↗

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism.Semantic proximity Read ↗

Cdc48 cofactor Shp1 regulates signal-induced SCFMet30 disassembly.Semantic proximity Read ↗

Overproduction of polypeptides corresponding to the amino terminus of the F-box proteins Cdc4p and Met30p inhibits ubiquitin ligase activities of their SCF complexes.Semantic proximity Read ↗

The amino-terminal portion of the F-box protein Met30p mediates its nuclear import and assimilation into an SCF complex.Semantic proximity Read ↗

The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle.Semantic proximity Read ↗

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition.Semantic proximity Read ↗

F-box proteins: more than baits for the SCF?Semantic proximity Read ↗

Identification of She3 as an SCF(Grr1) substrate in budding yeast.Semantic proximity Read ↗

A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32.Semantic proximity Read ↗

Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases.Semantic proximity Read ↗

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