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Article

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition.

The EMBO journal - 3 Apr 2000

Patton E E, Peyraud C, Rouillon A, Surdin-Kerjan Y, Tyers M, Thomas D

Abstract excerpt

Progression through the cell cycle requires the coordination of basal metabolism with the cell cycle and growth machinery. Repression of the sulfur gene network is mediated by the ubiquitin ligase SCF(Met30), which targets the transcription factor Met4p for degradation. Met30p is an essential protein in yeast. We have found that a met4Deltamet30Delta double mutant is viable, suggesting that the essential function...

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Identifiers

PMID: 10747029
DOI: 10.1093/emboj/19.7.1613
PMCID: PMC310230

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition.PMID 10747029Read ↗

The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle.Semantic proximity Read ↗

A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32.Semantic proximity Read ↗

Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.Semantic proximity Read ↗

The amino-terminal portion of the F-box protein Met30p mediates its nuclear import and assimilation into an SCF complex.Semantic proximity Read ↗

The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability.Semantic proximity Read ↗

Characterizing the roles of Met31 and Met32 in coordinating Met4-activated transcription in the absence of Met30.Semantic proximity Read ↗

Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p.Semantic proximity Read ↗

Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats.Semantic proximity Read ↗

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Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast.Semantic proximity Read ↗

Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins.Semantic proximity Read ↗

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