Article
Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37.
Molecular and cellular biology - 1 Nov 2009
Dukanovic Jovana, Dimmer Kai S, Bonnefoy Nathalie, Krumpe Katrin, Rapaport Doron
Abstract excerpt
The TOM complex is the general mitochondrial entry site for newly synthesized proteins. Precursors of beta-barrel proteins initially follow this common pathway and are then relayed to the SAM/TOB complex, which mediates their integration into the outer membrane. Three proteins, Sam50 (Tob55), Sam35 (Tob38/Tom38), and Sam37 (Mas37), have been identified as the core constituents of the latter complex. Sam37 is...
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