Article
Overproduction of polypeptides corresponding to the amino terminus of the F-box proteins Cdc4p and Met30p inhibits ubiquitin ligase activities of their SCF complexes.
Eukaryotic cell - 1 Feb 2003
Dixon Cheryl, Brunson Lee Ellen, Roy Mary Margaret, Smothers Dechelle, Sehorn Michael G, Mathias Neal
Abstract excerpt
Ubiquitin ligases direct the transfer of ubiquitin onto substrate proteins and thus target the substrate for proteasome-dependent degradation. SCF complexes are a family of ubiquitin ligases composed of a common core of components and a variable component called an F-box protein that defines substrate specificity. Distinct SCF complexes, defined by a particular F-box protein, target different substrate proteins...
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