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Article

UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

Cell - 6 May 2005

Sugasawa Kaoru, Okuda Yuki, Saijo Masafumi, Nishi Ryotaro, Matsuda Noriyuki, Chu Gilbert, Mori Toshio, Iwai Shigenori, Tanaka Keiji, Tanaka Kiyoji, Hanaoka Fumio

Abstract excerpt

The xeroderma pigmentosum group C (XPC) protein complex plays a key role in recognizing DNA damage throughout the genome for mammalian nucleotide excision repair (NER). Ultraviolet light (UV)-damaged DNA binding protein (UV-DDB) is another complex that appears to be involved in the recognition of NER-inducing damage, although the precise role it plays and its relationship to XPC remain to be elucidated. Here we...

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Identifiers

PMID: 15882621
DOI: 10.1016/j.cell.2005.02.035

Genes

XPC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.PMID 15882621Read ↗

DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.Semantic proximity Read ↗

SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.Semantic proximity Read ↗

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.Semantic proximity Read ↗

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.Semantic proximity Read ↗

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.Semantic proximity Read ↗

Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis.Semantic proximity Read ↗

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stabilitySemantic proximity Read ↗

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites.Semantic proximity Read ↗

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage responseSemantic proximity Read ↗

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.Semantic proximity Read ↗

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.Semantic proximity Read ↗

Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.Semantic proximity Read ↗

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