Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006

Kapetanaki Maria G, Guerrero-Santoro Jennifer, Bisi Dawn C, Hsieh Ching L, Rapić-Otrin Vesna, Levine Arthur S

Abstract excerpt

Xeroderma pigmentosum (XP) is a heritable human disorder characterized by defects in nucleotide excision repair (NER) and the development of skin cancer. Cells from XP group E (XP-E) patients have a defect in the UV-damaged DNA-binding protein complex (UV-DDB), involved in the damage recognition step of NER. UV-DDB comprises two subunits, products of the DDB1 and DDB2 genes, respectively. Mutations in the DDB2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Cullin Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Histones

Share to Ubiquitin

Share to Ubiquitin-Protein Ligases

Share to Ultraviolet Rays

Share to Xeroderma Pigmentosum

Source

Open in PubMed Open full text

Identifiers

PMID: 16473935
DOI: 10.1073/pnas.0511160103
PMCID: PMC1413840

Genes

DDB2
DDB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.PMID 16473935Read ↗

DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.Semantic proximity Read ↗

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.Semantic proximity Read ↗

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.Semantic proximity Read ↗

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.Semantic proximity Read ↗

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stabilitySemantic proximity Read ↗

Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.Semantic proximity Read ↗

UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.Semantic proximity Read ↗

Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.Semantic proximity Read ↗

Xeroderma pigmentosum group E and DDB2, a smaller subunit of damage-specific DNA binding protein: proposed classification of xeroderma pigmentosum, Cockayne syndrome, and ultraviolet-sensitive syndrome.Semantic proximity Read ↗

The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells.Semantic proximity Read ↗

Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Semantic proximity Read ↗

SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.