Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.

DNA repair - 2 May 2005

Matsuda Noriyuki, Azuma Keiko, Saijo Masafumi, Iemura Shun-Ichiro, Hioki Yusaku, Natsume Tohru, Chiba Tomoki, Tanaka Kiyoji, Tanaka Keiji

Abstract excerpt

Xeroderma pigmentosum (XP) is a genetic disease characterized by hypersensitivity to UV irradiation and high incidence of skin cancer caused by inherited defects in DNA repair. Mutational malfunction of damaged-DNA binding protein 2 (DDB2) causes the XP complementation group E (XP-E). DDB2 together with DDB1 comprises a heterodimer called DDB complex, which is involved in damaged-DNA binding and nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cricetinae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cullin Proteins

Share to Immunoprecipitation

Share to Ubiquitin

Share to Ubiquitin-Protein Ligase Complexes

Share to Ultraviolet Rays

Share to Xeroderma Pigmentosum

Source

Identifiers

PMID: 15811626
DOI: 10.1016/j.dnarep.2004.12.012

Genes

DDB2
DDB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.PMID 15811626Read ↗

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.Semantic proximity Read ↗

The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells.Semantic proximity Read ↗

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stabilitySemantic proximity Read ↗

DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.Semantic proximity Read ↗

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.Semantic proximity Read ↗

UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.Semantic proximity Read ↗

DDB2 association with PCNA is required for its degradation after UV-induced DNA damage.Semantic proximity Read ↗

Xeroderma pigmentosum group E and DDB2, a smaller subunit of damage-specific DNA binding protein: proposed classification of xeroderma pigmentosum, Cockayne syndrome, and ultraviolet-sensitive syndrome.Semantic proximity Read ↗

The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human PathologiesSemantic proximity Read ↗

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.Semantic proximity Read ↗

Tumor-prone phenotype of the DDB2-deficient mice.Semantic proximity Read ↗

p53 Binds and Activates the Xeroderma Pigmentosum <i>DDB2</i> Gene in Humans but Not MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.