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Article

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.

DNA repair - 1 Oct 2020

Beecher Maria, Kumar Namrata, Jang Sunbok, Rapić-Otrin Vesna, Van Houten Bennett

Abstract excerpt

UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are associated with xeroderma pigmentosum complementation group E. UV-DDB forms a ubiquitin E3 ligase complex with cullin-4A and RBX that helps to relax chromatin around UV-induced photoproducts through the ubiquitination of histone H2A....

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Identifiers

PMID: 32739133
DOI: 10.1016/j.dnarep.2020.102860
PMCID: PMC7873659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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