Article
A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.
Nucleic acids research - 20 Jun 2016
Ranes Michael, Boeing Stefan, Wang Yuming, Wienholz Franziska, Menoni Hervé, Walker Jane, Encheva Vesela, Chakravarty Probir, Mari Pierre-Olivier, Stewart Aengus, Giglia-Mari Giuseppina, Snijders Ambrosius P, Vermeulen Wim, Svejstrup Jesper Q
Abstract excerpt
Cockayne syndrome B (CSB), best known for its role in transcription-coupled nucleotide excision repair (TC-NER), contains a ubiquitin-binding domain (UBD), but the functional connection between protein ubiquitylation and this UBD remains unclear. Here, we show that CSB is regulated via site-specific ubiquitylation. Mass spectrometry analysis of CSB identified lysine (K) 991 as a ubiquitylation site. Intriguingly,...
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