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Article

DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.

Molecular and cellular biology - 1 Jun 2010

Takedachi Arato, Saijo Masafumi, Tanaka Kiyoji

Abstract excerpt

UV-damaged-DNA-binding protein (UV-DDB) is a heterodimer comprised of DDB1 and DDB2 and integrated in a complex that includes a ubiquitin ligase component, cullin 4A, and Roc1. Here we show that the ubiquitin ligase activity of the DDB2 complex is required for efficient global genome nucleotide excision repair (GG-NER) in chromatin. Mutant DDB2 proteins derived from xeroderma pigmentosum group E patients are not...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20368362
DOI: 10.1128/MCB.01460-09
PMCID: PMC2876528

Genes

DDB2
XPA
XPC
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.PMID 20368362Read ↗

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.Semantic proximity Read ↗

UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.Semantic proximity Read ↗

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.Semantic proximity Read ↗

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.Semantic proximity Read ↗

SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.Semantic proximity Read ↗

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stabilitySemantic proximity Read ↗

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites.Semantic proximity Read ↗

Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.Semantic proximity Read ↗

DDB2 association with PCNA is required for its degradation after UV-induced DNA damage.Semantic proximity Read ↗

Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.Semantic proximity Read ↗

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.Semantic proximity Read ↗

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage responseSemantic proximity Read ↗

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