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Article

Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.

Photochemistry and photobiology - 1 Jan 2000

Oh Kyu-Seon, Imoto Kyoko, Emmert Steffen, Tamura Deborah, DiGiovanna John J, Kraemer Kenneth H

Abstract excerpt

The xeroderma pigmentosum (XP-E) DNA damage binding protein (DDB2) is involved in early recognition of global genome DNA damage during DNA nucleotide excision repair (NER). We found that skin fibroblasts from four newly reported XP-E patients with numerous skin cancers and DDB2 mutations had slow repair of 6-4 photoproducts (6-4PP) and markedly reduced repair of cyclobutane pyrimidine dimers (CPD). NER proteins...

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Source

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Identifiers

PMID: 21388382
DOI: 10.1111/j.1751-1097.2011.00909.x
PMCID: PMC3082610

Genes

DDB2
CPD
XPA
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.PMID 21388382Read ↗

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