Article
Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis.
The Journal of biological chemistry - 26 Sept 2014
He Jinshan, Zhu Qianzheng, Wani Gulzar, Sharma Nidhi, Han Chunhua, Qian Jiang, Pentz Kyle, Wang Qi-En, Wani Altaf A
Abstract excerpt
Ubiquitin specific protease 7 (USP7) is a known deubiquitinating enzyme for tumor suppressor p53 and its downstream regulator, E3 ubiquitin ligase Mdm2. Here we report that USP7 regulates nucleotide excision repair (NER) via deubiquitinating xeroderma pigmentosum complementation group C (XPC) protein, a critical damage recognition factor that binds to helix-distorting DNA lesions and initiates NER. XPC is...
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