Article
Acetylation in histone H3 globular domain regulates gene expression in yeast.
Cell - 6 May 2005
Xu Feng, Zhang Kangling, Grunstein Michael
Abstract excerpt
In Saccharomyces cerevisiae, known histone acetylation sites regulating gene activity are located in the N-terminal tails protruding from the nucleosome core. We report lysine 56 in histone H3 as a novel acetylation site that is located in the globular domain, where it extends toward the DNA major groove at the entry-exit points of the DNA superhelix as it wraps around the nucleosome. We show that K56 acetylation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.