Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.

Current biology : CB - 11 Jul 2006

Celic Ivana, Masumoto Hiroshi, Griffith Wendell P, Meluh Pamela, Cotter Robert J, Boeke Jef D, Verreault Alain

Abstract excerpt

BACKGROUND: Acetylation of histone H3 lysine 56 (K56Ac) occurs transiently in newly synthesized H3 during passage through S phase and is removed in G2. However, the physiologic roles and effectors of K56Ac turnover are unknown. RESULTS: The sirtuins Hst3p and, to a lesser extent, Hst4p maintain low levels of K56Ac outside of S phase. In hst3 hst4 mutants, K56 hyperacetylation nears 100%. Residues corresponding to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Genome, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Histone Deacetylases

Share to Lysine

Share to Molecular Chaperones

Share to Niacinamide

Share to Sirtuins

Source

Identifiers

PMID: 16815704
DOI: 10.1016/j.cub.2006.06.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.PMID 16815704Read ↗

HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin.Semantic proximity Read ↗

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stabilitySemantic proximity Read ↗

Histone H3-K56 acetylation is important for genomic stability in mammalsSemantic proximity Read ↗

Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.Semantic proximity Read ↗

Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.Semantic proximity Read ↗

Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.Semantic proximity Read ↗

Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins.Semantic proximity Read ↗

Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.Semantic proximity Read ↗

Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.Semantic proximity Read ↗

A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability.Semantic proximity Read ↗

A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.