Article
Characterization of lysine 56 of histone H3 as an acetylation site in Saccharomyces cerevisiae.
The Journal of biological chemistry - 15 Jul 2005
Ozdemir Anil, Spicuglia Salvatore, Lasonder Edwin, Vermeulen Michiel, Campsteijn Coen, Stunnenberg Hendrik G, Logie Colin
Abstract excerpt
Post-translational histone modifications abound and regulate multiple nuclear processes. Most modifications are targeted to the amino-terminal domains of histones. Here we report the identification and characterization of acetylation of lysine 56 within the core domain of histone H3. In the crystal structure of the nucleosome, lysine 56 contacts DNA. Phenotypic analysis suggests that lysine 56 is critical for...
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