Article
Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.
Molecular cell - 7 Jul 2006
Maas Nancy L, Miller Kyle M, DeFazio Lisa G, Toczyski David P
Abstract excerpt
Histone modifications, including H3 K56 acetylation, have been implicated in DNA damage tolerance. Here, we present evidence that Hst3 and Hst4, two paralogues of the histone deacetylase Sir2, target the cell cycle-regulated acetylation of H3 on K56 and are downregulated during DNA damage in a checkpoint-dependent manner. We show that Hst3 and Hst4 are themselves cell cycle regulated and that their misexpression...
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