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Article

Subversion of T lineage commitment by PU.1 in a clonal cell line system.

Developmental biology - 15 Apr 2005

Dionne Christopher J, Tse Kevin Y, Weiss Angela H, Franco Christopher B, Wiest David L, Anderson Michele K, Rothenberg Ellen V

Abstract excerpt

Specification of mammalian T lymphocytes involves prolonged developmental plasticity even after lineage-specific gene expression begins. Expression of transcription factor PU.1 may maintain some myeloid-like developmental alternatives until commitment. Commitment could reflect PU.1 shutoff, resistance to PU.1 effects, and/or imposition of a suicide penalty for diversion. Here, we describe subclones from the...

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Identifiers

PMID: 15882585
DOI: 10.1016/j.ydbio.2005.01.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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