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Article

Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states.

Genes & development - 15 Nov 2016

Somasundaram Rajesh, Åhsberg Josefine, Okuyama Kazuki, Ungerbäck Jonas, Lilljebjörn Henrik, Fioretos Thoas, Strid Tobias, Sigvardsson Mikael

Abstract excerpt

Even though leukemia is considered to be confined to one specific hematopoietic cell type, cases of acute leukemia of ambiguous lineage and patients relapsing in phenotypically altered disease suggest that a malignant state may be transferred between lineages. Because B-cell leukemia is associated with mutations in transcription factors of importance for stable preservation of lineage identity, we here...

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Share to Cell Transformation, Neoplastic

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Source

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Identifiers

PMID: 27913602
DOI: 10.1101/gad.285536.116
PMCID: PMC5159664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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