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Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress

7 Apr 2015

Abstract excerpt

Understanding the critical factors that govern recovery of the hematopoietic system from stress, such as during anticancer therapy and bone marrow transplantation, is of clinical significance. We investigated the importance of the prosurvival proteins myeloid cell leukemia-1 (MCL-1) and B-cell lymphoma-extra large (BCL-XL) in stem/progenitor cell survival and fitness during hematopoietic recovery from stress....

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Identifiers

PMID: 25847014
DOI: 10.1182/blood-2015-01-621250

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