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Article

Clonal expansion of HTLV-1 infected cells depends on the CD4 versus CD8 phenotype.

Frontiers in bioscience (Landmark edition) - 1 Jan 2009

Zane Linda, Sibon David, Mortreux Franck, Wattel Eric

Abstract excerpt

As other deltaretroviruses HTLV-1 replication in vivo includes a first short step of reverse transcription that is followed by the persistent clonal expansion of infected cells. In vivo these cells include the CD4+ and CD8+ lymphocytes yet the virus induces adult T cell leukemia/lymphoma (ATLL) that is regularly of the CD4+ phenotype. Cloned infected cells from individuals without malignancy possess a dramatic...

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Identifiers

PMID: 19273324
DOI: 10.2741/3502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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