Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo.

Abstract excerpt

Paraxial mesoderm is the tissue which gives rise to the skeletal muscles and vertebral column of the body. A gene regulatory network operating in the formation of paraxial mesoderm has been described. This network hinges on three key factors, Wnt3a, Msgn1 and Tbx6, each of which is critical for paraxial mesoderm formation, since absence of any one of these factors results in complete absence of posterior somites....

Topics

• Animals
• Cell Differentiation
• Embryo, Mammalian
• Epithelial-Mesenchymal Transition
• Gene Expression Regulation, Developmental
• Mesoderm
• Mice
• Mutation
• Somites